JPH0550512B2 - - Google Patents

Info

Publication number
JPH0550512B2
JPH0550512B2 JP60146925A JP14692585A JPH0550512B2 JP H0550512 B2 JPH0550512 B2 JP H0550512B2 JP 60146925 A JP60146925 A JP 60146925A JP 14692585 A JP14692585 A JP 14692585A JP H0550512 B2 JPH0550512 B2 JP H0550512B2
Authority
JP
Japan
Prior art keywords
value
methyl
benzimidazole
kbr
nmr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP60146925A
Other languages
English (en)
Japanese (ja)
Other versions
JPS625966A (ja
Inventor
Masahiro Kise
Fusao Ueda
Shinichi Tanda
Masao Murase
Katsutoshi Kunimoto
Makoto Sugyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Shinyaku Co Ltd
Original Assignee
Nippon Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd
Priority to JP60146925A priority Critical patent/JPS625966A/ja
Priority to GB08614420A priority patent/GB2177393B/en
Priority to IT8648200A priority patent/IT1208460B/it
Priority to DE19863622036 priority patent/DE3622036A1/de
Priority to FR868609604A priority patent/FR2587341B1/fr
Priority to US06/881,647 priority patent/US4769384A/en
Publication of JPS625966A publication Critical patent/JPS625966A/ja
Publication of JPH0550512B2 publication Critical patent/JPH0550512B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/10—Radicals substituted by halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP60146925A 1985-07-03 1985-07-03 ベンズイミダゾ−ル誘導体 Granted JPS625966A (ja)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP60146925A JPS625966A (ja) 1985-07-03 1985-07-03 ベンズイミダゾ−ル誘導体
GB08614420A GB2177393B (en) 1985-07-03 1986-06-13 Benzimidazole derivatives
IT8648200A IT1208460B (it) 1985-07-03 1986-06-30 Derivati benzimidazolici utili come agenti antiulcera
DE19863622036 DE3622036A1 (de) 1985-07-03 1986-07-01 Benzimidazolderivate
FR868609604A FR2587341B1 (fr) 1985-07-03 1986-07-02 Derives du benzimidazole
US06/881,647 US4769384A (en) 1985-07-03 1986-07-03 Benzimidazole derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP60146925A JPS625966A (ja) 1985-07-03 1985-07-03 ベンズイミダゾ−ル誘導体

Publications (2)

Publication Number Publication Date
JPS625966A JPS625966A (ja) 1987-01-12
JPH0550512B2 true JPH0550512B2 (en]) 1993-07-29

Family

ID=15418672

Family Applications (1)

Application Number Title Priority Date Filing Date
JP60146925A Granted JPS625966A (ja) 1985-07-03 1985-07-03 ベンズイミダゾ−ル誘導体

Country Status (6)

Country Link
US (1) US4769384A (en])
JP (1) JPS625966A (en])
DE (1) DE3622036A1 (en])
FR (1) FR2587341B1 (en])
GB (1) GB2177393B (en])
IT (1) IT1208460B (en])

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5418245A (en) * 1990-04-16 1995-05-23 Rhone-Poulenc Rorer International (Holdings) Inc. Styryl-substituted monocyclic and bicyclic heteroaryl compounds which inhibit EGF receptor tyrosine kinase
US5196446A (en) * 1990-04-16 1993-03-23 Yissum Research Development Company Of The Hebrew University Of Jerusalem Certain indole compounds which inhibit EGF receptor tyrosine kinase
US5302606A (en) * 1990-04-16 1994-04-12 Rhone-Poulenc Rorer Pharmaceuticals Inc. Styryl-substituted pyridyl compounds which inhibit EGF receptor tyrosine kinase
US5656655A (en) * 1994-03-17 1997-08-12 Rhone-Poulenc Rorer Pharmaceuticals, Inc. Styryl-substituted heteroaryl compounds which inhibit EGF receptor tyrosine kinase
US6166219A (en) 1995-12-28 2000-12-26 Fujisawa Pharmaceutical Co., Ltd. Benzimidazole derivatives
CA2259585A1 (en) * 1996-07-05 1998-01-15 Mochida Pharmaceutical Co., Ltd. Benzimidazole derivatives having eosinophil increment inhibition activity and their use as medicament
TW453999B (en) 1997-06-27 2001-09-11 Fujisawa Pharmaceutical Co Benzimidazole derivatives
UA80393C2 (uk) 2000-12-07 2007-09-25 Алтана Фарма Аг Фармацевтична композиція, яка містить інгібітор фде 4, диспергований в матриці
MY140561A (en) * 2002-02-20 2009-12-31 Nycomed Gmbh Dosage form containing pde 4 inhibitor as active ingredient
EP1606261B1 (en) 2003-03-10 2009-11-04 Nycomed GmbH Novel process for the preparation of roflumilast
ES2421916T3 (es) 2005-03-16 2013-09-06 Nycomed Gmbh Forma farmacéutica de sabor enmascarado que contiene roflumilast
PT2035369E (pt) 2006-07-05 2014-09-30 Fibrotech Therapeutics Pty Ltd Compostos terapêuticos
EP2370425A4 (en) * 2008-12-26 2013-02-27 Glenmark Pharmaceuticals Sa IMIDAZOLE DERIVATIVES CONDENSED AS TRPV3 ANTAGONISTS
JP5680054B2 (ja) * 2009-04-02 2015-03-04 メルク セローノ ソシエテ アノニム ジヒドロオロテート脱水素酵素阻害剤
US8420235B2 (en) * 2009-06-04 2013-04-16 Nitto Denko Corporation Emissive diaryl acetylenes
US8323805B2 (en) 2009-06-04 2012-12-04 Nitto Denko Corporation Emissive aryl-heteroaryl acetylenes
SG10201501272SA (en) * 2009-10-22 2015-04-29 Fibrotech Therapeutics Pty Ltd Fused ring analogues of anti-fibrotic agents
MX2019009235A (es) 2017-02-03 2019-12-11 Certa Therapeutics Pty Ltd Compuestos antifibroticos.

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2170474A (en) * 1936-03-18 1939-08-22 Soc Of Chemical Ind Benzimidazoles and process of making same
US3075991A (en) * 1960-01-20 1963-01-29 Dow Chemical Co Benzimidazolylalkylbenzene-sulfonamide compounds
US3152142A (en) * 1962-05-24 1964-10-06 Dow Chemical Co Benzimidazole compounds
FR1488318A (fr) * 1966-04-27 1967-07-13 Chimetron Sarl Dérivés sulfénylés de vinylbenzimidazoles
DE1670908A1 (de) * 1967-08-16 1971-04-29 Hoechst Ag Neue Benzimidazolverbindungen,Verfahren zu ihrer Herstellung und ihre Verwendung als optische Aufhellungsmittel
CH490010A (de) * 1967-10-26 1970-05-15 Ciba Geigy Schädlingsbekämpfungsmittel
DE2060939A1 (de) * 1970-12-11 1972-06-15 Agfa Gevaert Ag Spektral sensibilisiertes photographisches Schnellverarbeitungsmaterial
DE2320528A1 (de) * 1973-04-21 1974-11-07 Hoechst Ag Verfahren zur herstellung von acetylenen
JPS5020080A (en]) * 1973-06-06 1975-03-03
JPS51125078A (en) * 1974-07-01 1976-11-01 Lilly Co Eli Production of substituted 11sulphonylbenzimidazole
GB2053215B (en) * 1979-06-25 1983-04-07 May & Baker Ltd Benzimidazole derivatives

Also Published As

Publication number Publication date
GB2177393B (en) 1989-02-01
US4769384A (en) 1988-09-06
IT8648200A0 (it) 1986-06-30
IT1208460B (it) 1989-06-12
GB2177393A (en) 1987-01-21
GB8614420D0 (en) 1986-07-16
JPS625966A (ja) 1987-01-12
FR2587341B1 (fr) 1990-05-25
DE3622036A1 (de) 1987-01-22
FR2587341A1 (fr) 1987-03-20

Similar Documents

Publication Publication Date Title
JP6704421B2 (ja) Ｄｎａアルキル化剤
JPH0550512B2 (en])
US4822805A (en) Pyridyl-imidazole compounds which have useful pharmaceutical activity
DE69016125T2 (de) Chinolin-Derivate, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel.
EP0268989B1 (en) Imidazopyridine compounds and processes for preparation thereof
EP2415767B1 (en) Poly (ADP-ribose) Polymerase (PARP) Inhibitors
US5348962A (en) Hydroxyquinolone derivatives compounds which have pharmaceutical utility
JP5137586B2 (ja) 新規のベンゾイミダゾール誘導体及びこれを含む薬剤学的組成物
BG60428B2 (bg) Бензимидазоли,метод за получаването им и лекарствени средства, които ги съдържат
JP2007528362A (ja) 置換アリールアルカン酸誘導体及びその用途
CA2890003A1 (en) Amine derivatives or salt thereof as tnf"alpha"inhibitors
EP0544821A1 (en) INDOLE DERIVATIVES FOR USE AS ANTIALLERGIC AND ANTI-INFLAMMATORY AGENTS.
JPH0853447A (ja) 新規１，３−ジヒドロ−２Ｈ−ピロロ〔２，３−ｂ〕ピリジン−２−オンとオキサゾロ〔４，５−ｂ〕ピリジン−２（３Ｈ）−オン化合物、その製造方法及びそれらを含む薬剤組成物
JP2016094432A (ja) キナーゼインヒビター、そのプロドラッグ型および治療におけるそれらの使用
NO147879B (no) Analogifremgangsmaate for fremstilling av terapeutisk virksomme 2-substituerte benzimidazoler
WO2011148956A1 (ja) 縮合イミダゾール誘導体
JP5331953B2 (ja) 代謝性障害の治療のための３−アミノ−ピリジン誘導体
JPH0471914B2 (en])
US4791114A (en) 2-Benzimidazolylalkylthio (or -sulfinyl or -sulfonyl) derivatives, their preparation and their application as medicinal products
KR900003649B1 (ko) (1H-테트라졸-5-일)테트라졸로[1,5-a]-퀴놀린의 제조방법
JPH07119188B2 (ja) カルコン誘導体
JPH06135943A (ja) 新規なウラシル誘導体及びそれを有効成分とするアレルギー疾患治療薬
KR20190126525A (ko) 신규 소듐채널 저해 화합물, 이의 제조방법, 및 이를 포함하는 소듐채널 관련 질환의 예방 또는 치료용 약학적 조성물
JPS6325585B2 (en])
JPH01157955A (ja) 新規複素環誘導体およびその製造法